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#51
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No idea. It should kick some serious ass though
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#52
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I think this may be the case after skimming the full text. I have a ton to say on this issue and in critique of the results and parameters. Maybe we can discuss this in the science section? I think this is a very useful discussion when it comes to MANY compounds, nonetheless.
Yes, but that still points to my argument on there being confounding variables and already having or getting a legion during this long ~10 year study. I should also mention it is very interesting that this is in Norway where there are no folic acid fortified foods. I wonder if the results would be different in America where general folic acid consumption is higher and we are more "adapted" to a higher consumption amount? Quote:
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I should also point out that there are other reasons glycerol was added to the formula. Increasing plasma volume will also help to eliminate the headaches and other possible negative side effects from the nitrates. I, personally, think its induction to this formula is ingenious. Quote:
I should reiterate that dose dependence is a major issue here (how much was arginase risen when citrulline malate was added vs. arginine per gram of each). Arginine nitrate is cheaper too. |
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#53
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I'm pretty sure it won't be since it's an add-on to p-bol.
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#54
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The effect of folic acid is hypothesis to have a U shape. With low levels resulting in increased cancer risk, moderate levels a lower cancer risk and high levels an increased risk. The further right you are on this spectrum (having high consumption prior to supplementation), the more fucked you are. I wasn't talking to you, and it didn't need an answer. Quote:
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Entirely different compounds? Citrulline increases plasma ARGININE. How is citrulline a completely different substance? |
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#55
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Taken as a whole, I think we can both agree that folic acid may cause problems if you ALREADY have cancer. This study was done over the course of 10 years and NO ONE will be taking c-bol for 10 years straight (it is meant to be cycled and at thermolife we advocate the cycling of all supplements). If you have cancer, don't take folic acid. If you are older or are in a risk group for cancer, don't take folic acid. Quote:
Who knows what a previous higher amount of consumption means...it's an idea. I should also point out that if they did this exact same study using high protein diets instead of folic acid, the results would be similar. Well, you got one and it's pertinent to the conversation. i.e. U-shaped curve. Quote:
I don't quite understand what you need to be convinced of? It increases plasma volume (which is beneficial to the formula as a whole) and I'm telling you now that the addition will help with cell volumization and the "pump" effect. It certainly has its place in P-BOL. This is a pump product, and glycerol does that. Quote:
Again, think about what I said above. PRICE. Gram for Gram effectiveness of each compound alone and how/if they will provide comparable results. Last edited by ThermoRep; 06-27-2010 at 03:12 PM. |
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#56
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If supplementation would be benefical, it would be in countries with no fortification and are on that left side of the curve. Yet in in such a country (Denmark), the supplement increased cancer risk. Quote:
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Citrulline might cost more but it increases plasma arginine better and has other benefits. If you want to play the price game, than I'm going to argue that creatine monohydrate is a better buy than pump-bol. |
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#57
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Don't you think that if folic acid were carcinogenic, those who ate diets high is greens (which contain high levels of folate) would have a significantly higher cancer rate (which is opposite)? Wouldn't the entire animal kingdom that relies on vegetation to eat be overrun with cancer (which again, is opposite)? Evolutionarily, it doesn't make sense. In addition, I should reiterate that if this study were performed with high protein diets, casein supplementation, etc, the results would be comparable. Nonetheless, there is much we don't know about folic acid supplementation and I would love to see some more data on the issue. I just think it's extremely premature to assert folic acid is carcinogenic in the least at this point in time...and given how folate works (its a source of carbon in the synthesis of nucleotides that are essential for DNA replication and repair) its almost common sense to me that it would not be smart to take if you had cancer, but in no way can I see it being carcinogenic. Keep in mind we are cycling C-BOL and not using it for periods of 10 years, and at that, we are in COMPLETELY different physiological states then the subjects used (we may allow and even require a higher daily folic acid intake than those who are older AND not working out). In the spirit of true randomization, I would loved to have seen data on a larger (younger) age spread of individuals. Before I forget, as an aside, I would have liked to see different doses of folic acid used in the study (i.e. 200, 400, 800) to give us an idea of what this number is. BACK TO P-BOL! Quote:
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If you think creatine monohydrate is a better buy than p-bol, then by all means use that instead. Last edited by ThermoRep; 06-28-2010 at 06:48 PM. |
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#58
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Both of those arguments are extremly poor from an evidence based perspective, I'm sure you know that. Quote:
Besides, folic acid has other roles than nucleotide synthesis, like methylation, which makes it possibly carcinogenic. Quote:
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I don't know from the top of my head and I'm to lazy to look it up now because I don't think the exact number means that much. It raises plasma arginine levels higher than arginine itself + has performance benefits + it's not like the price is crazy high so differences will be relative marginal. But since you care about effectiveness per $ so much, could you explain why there is turk in E-bol which is much more expensive than edcy, and not likely more effectve in that same magnitude? |
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#59
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Don't play dumb lol. Insuline, GH, etc. The simple fact that oral arginine and IV arginine lead to significantly different effects tells us this. Quote:
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In this regard, arginine was found to be completely effective at combating nitrate tolerance. Don't know how much better you can get. We are not talking about pumps here, or anabolism, or another issue where there is no limit w/r to effectiveness by increasing it. Well, turk actually IS MUCH MUCH more effective than ecdysterone itself, especially when combined with ecdysterone. Last edited by ThermoRep; 06-30-2010 at 06:04 PM. |
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#60
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Also, we I believe we will be coming out with a citrulline nitrate product eventually so more power to you if you want to try that along with nitrates/p-bol.
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#61
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Damnit, I just want it to be out.
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#62
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Your main argument is that arginine has a proven effect in contrast to citrulline malate right? That is a fair argument, if you have that opinion consistently. Show me human data that T.Atlantus is effective in humans for example? I'm not saying that it isn't, just that you guys are making a leap of faith based on animal data. And there is nothing wrong with that, you have to do so in order to be innovative. But my point is that you have to choose, use evidence based ingredients or make some leaps of faiths. Heck you can do both if you want, but if you do, don't give me the 'yeah we go for the evidence based route' when it suits you in an argument. Same thing with price. Can the costs of an ingredient play are role in a formulation? Ofcourse! But how important is that role with this product? Do you agree with me, that creatine monohydrate is the best buy in the sport supplement industry $ for $? That means that people who buy P-bol, are not people who are interested in buying the best buy $ for $, they are willing to pay extra for products that might have some additional benefits, even though the benefits are relatively much smaller than the additional price of the product. Do you think that those people care much about the slightly bigger price of citrulline compared to arginine? You also say you would need more of it? Why would you need more of it? For the same plasma arginine raise, you would need less. If you mean for the ergogenic effects, yes you need more, but than you actually get more. Quote:
The graph here on my E-bol packing says otherwise. |
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#63
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Once again, we don't know if citrulline works for this purpose, and with regard to innovation, arginine nitrate has never been used before. We have citrulline nitrate patented so maybe it will be an option in the future. Who knows, we just have to take this one step at a time and see how P-BOL works first. No, the difference in the turk number and the ecdy number is significant. Also, 1+1=2....or 1.5....you'd have to ask Bane on that one. haha. That is why we use a spectrum extract. |
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#64
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More interested in the p-bol, clear-bol and weight gainer.
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#65
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I'm excited for the gainer too.
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#66
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I wanna know the carb source
![]() And also the protein source, but not as much.I hope it will be micellar casein. |
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#67
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Probably will be a blend just like vasolate with micellar casein being the first protein source.
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#68
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That's what I would suspect as well. I'm very curious what Bane has up his sleeves wrt carb sources.
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#69
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Eta!!! I Wants It Pleeez!!
__________________
*~*comprehensive Thermolife Vasolate review*~*: http://www.thermolife.com/forum/show...4659#post24659 BE all you can BE (Bio Pro and EBOL): http://forum.bodybuilding.com/showth...#post513792193 |
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#70
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Hells yes. Not a lot of healthy gainers out there
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#71
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Huh, so what is your argument than?
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1000g costs $22 serving size is 3g, so 1000/3 is about 333. $22/333 = about $0,06 The size of a serving of C-bol (assmuming P-bol will something like that) is 300 caps for $40. serving size is 6 caps (lets say you only take 1 serving a day, needless to say, it becomes much worse at 2 servings a day) = 50 days. 40/50 = $.80 a day 0.80/0,06 = 13,333 In order for C-bol to be just as good buy $ for $, it has to result in 13,33333 times as much gains as creatine monohydrate with one serving a day.....lol do you really think that? Quote:
It is not the same multitude more effective as difference in price. And you should have done your research before you made statements about it. ![]() |
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#72
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cause the price on delivery cost from US to EU on weight gainers and protein powders is way too much.I think if I was to just get a 10lb average weight gainer delivered to Ireland it would cost about its price to just deliver it. |
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#73
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#74
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If you are concerned with knowing the product works from a consumer stand point, there are multiple blood work panels done from forum users and Dr. P that you can find, reviews to look over, and our product guarantee to assure you will be satisfied. For you, no. For us, yes. We need to be confident the product works ![]() Quote:
I am a non-responder to monohydrate. If you want to compare the two, then they should have the same effects (granted at different intensities). Quote:
If you are so concerned with P-BOL containing citrulline, then buy some and add it yourself. |
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#75
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