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Old 04-20-2017, 09:45 AM
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Default Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.

Cell Metab. 2016 Jun 21. pii: S1550-4131(16)30247-9. doi: 10.1016/j.cmet.2016.05.025. [Epub ahead of print]
Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.

Moon HY1, Becke A2, Berron D2, Becker B1, Sah N1, Benoni G1, Janke E1, Lubejko ST1, Greig NH3, Mattison JA4, Duzel E5, van Praag H6.
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Abstract

Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is important for the cognitive and neurogenic benefits of running. Proteomic analysis revealed elevated levels of CTSB in conditioned medium derived from skeletal muscle cell cultures treated with AMP-kinase agonist AICAR. Consistently, running increased CTSB levels in mouse gastrocnemius muscle and plasma. Furthermore, recombinant CTSB application enhanced expression of brain-derived neurotrophic factor (BDNF) and doublecortin (DCX) in adult hippocampal progenitor cells through a mechanism dependent on the multifunctional protein P11. In vivo, in CTSB knockout (KO) mice, running did not enhance adult hippocampal neurogenesis and spatial memory function. Interestingly, in Rhesus monkeys and humans, treadmill exercise elevated CTSB in plasma. In humans, changes in CTSB levels correlated with fitness and hippocampus-dependent memory function. Our findings suggest CTSB as a mediator of effects of exercise on cognition.
Published by Elsevier Inc.

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. - PubMed - NCBI
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