Using PUMP-BOL is easy. As a dietary supplement, mix one to two (1-2) servings in 8-10 oz of cold water and consume 30-45 minutes pre-workout. First time users should start with one (1) serving to assess tolerance and work your way up to two (2) servings before workouts. Do NOT exceed recommended serving size.
Excellent question, and the answer is YES. But you will want to employ a bit of timing strategy and limit your dose of C-BOL to one serving per day (as both formulas contain nitrates). On training days, consume one serving of C-BOL in the morning. Then, 30-60 prior to training, consume 1 serving of PUMP-BOL. On non training days, consume one serving of C-BOL in the morning. This program will help keep you pumped all day, every day.
If you train first thing in the morning, take a serving of PUMP-BOL 30-60 minutes before training. Then, take a serving of C-BOL with your post workout shake.
If you train later in the evening, take one serving of C-BOL in the morning and one serving of PUMP-BOL 30-60 minutes prior to training.
This is an important question to know the answer to. It is safe to take ONE serving of Vasolate per day while using C-BOL and PUMP-BOL.
That's a great question, and we are glad you asked. By now it is no secret that L-arginine is incapable of boosting nitric oxide levels in healthy humans. While an arginine deficiency can hinder NO production and endothelial function, it can also prevent nitrate tolerance in humans(26). Tolerance to nitrates, as with stimulants, can develop with continued use over time. This allows PUMP-BOL to work just as good four months from now as it does today.
No, the Nitrate Ultra Pump Matrix is designed to address multiple key factors to create the biggest, longest lasting muscular pumps and contains multiple ingredients to accomplish that goal. Following is a detailed discussion for each ingredient found inside PUMP-BOL's Nitrate Ultra Pump Matrix.
Nitrates (as Arginine Nitrate and Beta-Alanine Nitrate)
Thermolife was the first company to introduce nitrates as NO boosters, performance enhancers, and also holds various patents of their use. The successful use of nitrates in C-Bol and Vasolate are followed up in PUMP-BOL. For anyone unfamiliar with nitrates and their advantages, here is a brief summary.
Lots of people use today NO products to increase "pumps", vasodilation, nutrient transportation to the muscle, aerobic performance, and recovery. All these products up to date had arginine as their base, which recently proved to be totally ineffective for actually raising NO levels. In fact most of the "pump" feeling comes from an insulin increase following Arginine supplementation (13). Nitrates have been used in the pharmaceutical industry for decades to induce direct and fast vasodilation. You see, nitrites and nitrates are inert end-products of NO oxidation. In addition, they can be recycled back to bioactive NO and this pathway is an important alternative to the classical L-arginine-NO-synthase pathway(14). This creates a powerful vasodilating effect which actually helps with nutrient absorption and distribution while increasing athletic performance(15). Since nitrates are naturally abundant in many vegetables and also present in meat, their safety is well established. In fact, in a recent study researchers provided the subjects with 700mg of nitrate per day and as they said "The BR supplementation regimen implemented in this study was well tolerated with no deleterious side effects". The beneficial effects of nitrate supplementation included lower BP, 20% less needed oxygen for muscle work, and increased time to failure". (16)
And there is even more beauty to the nitrate moiety. Organic nitrates also act as a permeation enhancer. That means that they increase intestinal absorption of not only the bonded molecule but ALL nutrients co ingested. They are even able to allow absorption of large macromolecules as insulin(17,18,19)!
ASCORBIC ACID
Ascorbic acid is also commonly known as Vitamin C, and Vitamin C's numerous benefits are well established. Ascorbic Acid's role in PUMP-BOL is two-fold.
Firstly, Nitric Oxide production from nitrate produces free radicals in the bloodstream(20,21). Hence Vitamin C, possessing powerful anti-oxidant activity, was added to help protect against damaging free radicals.
Second, prolonged use of nitrates may cause tolerance, thus minimizing their effects. The reason nitrate tolerance occurs is because NO production wastes the body's glutathione levels. The suggested mechanism in brief is: RONO2+GSH->GS-NO2->H +NO2->NO. In this mechanism, Glutathione(GSH) binds to NO2 via the enzyme Glutathione-S-transferase and after the production of NO2 the GS leftover binds with another molecule of Glutathione to create GS-SG. In brief words, for one molecule on NO to be created in the body, two molecules of Glutathione must be spent. It is also speculated that oxidative stress that NO production causes further enhances Glutathione depletion. (22,23,24,25). Of the various strategies used to overcome nitrate tolerance, Vitamin C supplementation has proven effective(25), much moreso than other popular antioxidants.
ARGININE NITRATE:
Yet another compound to be first introduced by Thermolife. Many of you will wonder why we chose to include Arginine when we have already established that Arginine is ineffective to boost nitric oxide levels in healthy athletes. While this is true (although an Arginine deficiency can hinder NO production and endothelial function), there is a particular property of Arginine that makes it's inclusion in a nitrate based NO product worthy. Arginine can successfully prevent nitrate tolerance in humans (26).
FOLIC ACID:
Another important nutrient for human health and performance, folic acid is also important for the regeneration of compounds required for the body's natural NO production. Research has demonstrated that folic acid supplementation prevents both nitrate tolerance and reduction of the body's endogenous NO production(27,28).
RESVERATROL:
A natural phytoalexin found in Red wine, resveratrol has been put to great use in today's sports and health supplements due to it's many beneficial effects. Such beneficial effects include cardiovascular protection, antioxidant activity, testosterone boosting, improvement of sperm count and health, and so forth.
Of particular interest for it's use in PUMP-BOL is resveratrol's effect on skeletal muscle. Resveratrol can increase the size and content of mitochondria as well as the mitochondrial enzyme activity in nonoxidative muscle fibers. This contributes to an increase in maximal oxygen consumption by those fibers (29).
Resveratrol has also been shown to protect mice from insulin resistance while on a high fat diet (30), in addition to stimulating glucose uptake by skeletal muscle. Some have even shown that resveratrol can stimulate glucose uptake independent of the action of insulin as well as enhance insulin-dependent glucose transport (31).
In addition, resveratrol has been consistently shown to inhibit protein degradation and to attenuate the atrophy of skeletal muscle fibers in vitro (32). Resveratrol possesses strong antioxidant effects and can protect muscle cells from injury and death (33). Of even greater interest in the PUMP-BOL formula is resveratrol's effect on vascular function. Not only is Resveratrol a strong vasorelaxant agent (34,35), but it can also prevent nitrate tolerance(36).
A major drawback of Resveratrol in oral human use is its limited bioavailability due to extensive glucuronidation and sulfation by the intestines and liver. To counter this, resveratrol was coupled in PUMP-BOL with powerful Glucuronidase and Sulfatase inhibitors.
QUERCETIN:
Quercetin is another natural compound with a myriad of beneficial effects, and it has found great use in many sports and health supplements applications. Quercetin was added to the PUMP-BOL formula for four reasons.
The PlasmaVolic Matrix consists of Glycerol bonded to the electrolytes sodium, potassium, and magnesium glycerolphosphate.
Glycerol is a natural polyalcohol that acts as an osmotic plasma volumizer.
In simple words it attracts water molecules, thus increasing the volume of plasma and hydration. Therefore, it can have ergogenic potential in sports where dehydration is a concern(41). Another interesting property is its capacity to maintain blood pressure at normal levels under conditions where it would otherwise drop, such as through vasodilatation or dehydration. While small drops in blood pressure can be considered healthy, big decreases can cause unwanted side effects like dizziness and headaches. Thus the addition of a plasma volumizer like glycerol can help maintain healthy blood pressure while not countering the beneficial effects of vasodilation.
A problem with Glycerol however is that it is a liquid. This makes is challenging to add into powdered products. Most companies have tried to overcome this by using Glycerol Monostearate(GMS), a form of glycerol bonded with the fatty acid Stearic Acid. Such an approach is terrible, as not only Stearic Acid has a substantial caloric value and is utterly useless, but also because GMS wields about only 30% of it's weight in Glycerol. The remaining 70% is useless fat, and you're not paying for fats, right? Right. The glycerol used in PUMP-BOL not only delivers a higher yield of beneficial Glycerol, it also delivers incredibly useful electrolytes. And speaking of electrolytes...
ELECTROLYTE COMPLEX: (Consisting of Sodium, Potassium, Magnesium and Phosphate ions)
The importance of electrolytes for bodily function and sports performance is well known. Electrolyte depletion during exercise can severely affect performance. It can also lower blood pressure to uncomfortable levels. Not only does PUMP-BOL deliver a sufficient dose of the basic electrolytes, but PUMP-BOL also includes a hefty dose of magnesium. Magnesium can prevent muscle cramping (42,43). And that's a great thing because a deficiency in magnesium increases the risk for muscle injury and cramping (43). And, magnesium's ergogenic and performance enhancing attributes have also been well established (44,45,46)
The Proton Flush Complex consists of beta-alanine (as free form beta-alanine and beta-alanine nitrate), creatine (as dicreatine malate), and creatinol-o-phosphate (aka, COP).
BETA-ALANINE: (As free form beta-alanine and beta-alanine nitrate)
Beta-alanine is a precursor to carnosine, a dipeptide found in skeletal muscle tissue which removes hydrogen ions from the cell. Accumulation of Hydrogen ions inside the muscle cell causes the "burn" feeling that results in muscle fatigue and failure. Boosting carnosine stores through supplementation with beta alanine has been shown to improve athletic performance and body composition, with effective doses starting at about 2 grams per day (47,48). However, optimal results with beta-alanine supplementation have been achieved when combined with creatine and high-intensity interval training(49, 50,51). And speaking of creatine...
CREATINE: (As Dicreatine Malate)
Dicreatine malate is a well known and researched nutritional supplement with scientifically proven effects in improving performance and body composition. It also has a synergistic role in reducing muscle cell acidosis.
CREATINOL-O-PHOSPHATE: (COP)
An analogue of creatine, COP cannot increase ATP levels like creatine can. However it can significantly boost muscle function by reducing intracellular lactate/H+ concentrations. COP can also boost cardiac function(52,53) and increase muscle strength (54).
Excellent question! ThermoLife scientists fueled PUMP-BOL with a powerful Brain & Body Fuel Matrix consisting of malic acid and palatinose.
MALIC ACID: (As free form L-Malic Acid and Dicreatine Malate)
Malic acid is a natural dicarboxylic acid. Its importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions, where a buildup of excess reducing equivalents inhibits glycolysis, malic acid's simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxias inhibition of glycolysis and energy production. It is of no wonder that malic acid supplementation can reduce fatigue, improve muscle performance, increase cognitive performance and increase glycogen stores (55,56,57,58). Despite all these wonderful properties, supplement companies have failed to introduce a sufficient dose of malic acid in their supplements, being content with the small amount found in malic acid salts like Creatine or Citrulline Malate. PUMP-BOL is the first supplement to utilize an efficient dose of malate for it's very own beneficial properties.
PALATINOSE
Also known as Isomaltulose, palatinose is a sugar analogue found in sugar cane and honey. Simple carbs like sugar and dextrose have a high GI index. This can cause blood glucose fluctuations, resulting in what is known as the "carb crash." Palaatinose however has a low GI index value (the lower the value, the slower the carbohydrate digests) and is low-insulinemic. Therefore, palatinose can deliver greater levels of energy than sugar, as it will not deliver a "sugar crash."
Being low-insulinemic, Paltinose also supports improved fat oxidation during physical activity as high insulin levels (triggered by simple sugars found in many pre-workout powders) hinder the use of lipids as an energy source. Thus palatinose can increase the amount of fat used as energy, enhancing athletic performance (59). The stable glucose levels that palatinose creates also have a positive effect in mental concentration, even when only 5 grams of palatinose are ingested (60). PUMP-BOL is incredibly suitable for people on low-carb diets, and it can provide the bodily and mental support that carbs deliver.
Stacking two or more products, each of which addresses a different contributing factor to muscular growth and strength enhancment, is a fantastic way to accelerate your gains. For the absolute best gains in strength and performance enhancement, we strongly recommend stacking PUMP-BOL with C-BOL. This powerful combination will supersaturate your muscle tissue with torque generating creatine levels while delivering the most jaw-dropping muscular pumps. It's the perfect pre, intra, and post workout support combination.
PUMP-BOL can also be combined with T-BOL, ThermoLife's premier natural testosterone booster. T-BOL is testosterone enhancement done RIGHT. Free from harmful aromatase inhibitors, T-BOL is the strongest natural testosterone boosting formula on the market today. Working WITH your body, rather than against it, T-BOL was designed to massively increase BOTH total testosterone and free testosterone for unsurpassed advancements in lean mass acquisition and strength enhancement. T-BOL is not a pro-hormone and does not require a post cycle therapy.
And, PUMP-BOL can also be combined with E-BOL, a powerful non-hormonal anabolic growth matrix. E-BOL is considered the "holy grail" in muscle building sports supplementation, mimicking the potent anabolic properties of hormones and pro-hormones without any of the unwanted androgenic side effects. The revolutionary E-BOL matrix signals muscle cells into an anabolic (growth) state, increasing nitrogen retention and converting more of your dietary protein intake into lean muscle mass. E-BOL also possesses dual adaptogenic effects that effectively "auto adjust" your physiological systems according to your own individual needs. In turn, this permits anabolism to excel and your physique and performance to break through previous "sticking points". This adaptogenic-anabolic effect is uniquely elicited by E-BOL, defining it as a breakthrough category in bodybuilding supplements.
We are glad you asked. PUMP-BOL is recommended for those who are 18 years of age and older.
That is always a great question to ask. While PUMP-BOL is 100% natural, it is always best to check FIRST with your testing organization and obtain approval and permission before using PUMP-BOL.
Yes, we do.
As the president of ThermoLife International I have made sure that every one of our products meets label claims and does exactly what it is intended to do. I am so sure of this that we offer a 100% money back guarantee on every product that we sell. If for any reason you are not satisfied with a product purchased from this web site, just send it back with a copy of your receipt and you will receive a full refund.
Ron Kramer
President
ThermoLife International
Send returns to:
Product Returns
c/o ThermoLife International LLC
3941 E. Chandler Blvd. #106-212
Phoenix, AZ 85048
You can email your question to contact@thermolife.com and our resident experts will get an answer for you asap! And if we think that your question can help others, we will post it right here!
Walter AA, Herda TJ, Ryan ED, Costa PB, Hoge KM, Beck TW, Stout JR, Cramer JT. Biophysics Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma, USA. jcramer@ou.edu.
Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y, Kubota K, Watanabe T. Graduate School of Nutritional and Environmental Sciences, COE Program in the 21st Century, University of Shizuoka, Shizuoka 422-8526, Japan.
Zhang W, Xu YC, Guo FJ, Meng Y, Li ML. Department of Endocrinology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Subash Babu P, Prabuseenivasan S, Ignacimuthu S. Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India.
Katoh M, Yoshioka Y, Nakagawa N, Yokoi T. Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
de Santi C, Pietrabissa A, Mosca F, Pacifici GM. Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, I-56126 Pisa, Italy.
De Santi C, Pietrabissa A, Spisni R, Mosca F, Pacifici GM. Department of Neurosciences, Medical School, Pisa, Italy.
Takahama U, Yamamoto A, Hirota S, Oniki T. Kyushu Dental University, Kitakyushu 803-8580, Japan. taskahama@kyu-dent.ac.jp
López-López G, Moreno L, Cogolludo A, Galisteo M, Ibarra M, Duarte J, Lodi F, Tamargo J, Perez-Vizcaino F. Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain. fperez@med.ucm.es
Van Thienen R, Van Proeyen K, Vanden Eynde B, Puype J, Lefere T, Hespel P. Department of Biomedical Kinesiology, Research Centre for Exercise and Health, Katholieke Universiteit Leuven, Leuven, Belgium.
Smith AE, Moon JR, Kendall KL, Graef JL, Lockwood CM, Walter AA, Beck TW, Cramer JT, Stout JR. Department of Health and Exercise Science, Metabolic and Body Composition Laboratory, University of Oklahoma, Norman, OK 73019, USA.
Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL, USA. rzoeller@fau.edu
Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J. Dept. of Health and Exercise Science, The College of New Jersey, Ewing, NJ 08628, USA.
Marchetti G, Merlo L.
Marzo A, Ghirardi P.
Nicaise J.
Only Loyal T "trustees" will be entitled to:
* Exclusive Deals & Discounts
* Free Training & Nutrition Tips
* Pre-release Supplement Offers
* Scientific Bulletins
* Plus Much Much Much MORE!